Distinct Role of Estrogen and Er (Α and Β) in Various Brain Disease Anomalies

Estrogens, the primary ovarian hormones and are accountable for the proliferation of cells and tissues linked to reproduction [1]. Along with the functions on female reproductive system, estrogens also play a pivotal role in the maintenance of physiological and pathological states including central nervous system physiology [2,3]. Due to this wide regulatory control, it is accepted that estrogens have chief functions not only in female but also in male physiology [4]. Although the physiological importance of estrogen and its mechanisms of actions has significantly enlightened, however, we are only beginning to decipher the roles of estrogen receptors (α and β) in different organs and to elucidate how subtype selective ligands acting through these receptors, can prevent or treat various diseases. Thus distinctive role of ER-α and β in various brain disease anomalies has been reviewed here in.